Mounjaro 2.5mg

2.5mg is the standard starting dose of Mounjaro (tirzepatide). It’s used for the first 4 weeks to:

• Help your body adjust to the medication
• Minimise risk of nausea and other side effects
• Prepare you for dose increases (to 5mg and above)

• Typical duration – 4 weeks
• Injection – Once weekly
• Common side effects – Mild nausea, bloating, fatigue
• Expected weight loss – Minimal (the next dose usually drives results)
• Next step – 5mg (after review with a clinician)

You can start your Mounjaro journey from home – no GP visit needed. Here’s how it works with our service:

1. 📝 Complete a short online assessment

2. 🩺 A clinician reviews your answers

3. 💊 If appropriate, you’ll be prescribed Mounjaro

4. 📦 Your first dose is delivered discreetly to your door

The first step is the online assessment. It typically takes 5-10 minutes and is required to make sure that any weight loss treatment we prescribe is likely to be safe and effective for you. It’s the first step towards sustainable weight loss.

A Mounjaro 2.5mg pen costs £129 for the first 4 weeks. That’s equivalent to £4.61/day!

Subsequent 2.5mg pens cost £179 (£6.39/day).

Mounjaro is taken once a week via a small injection (usually into your stomach, thigh, or upper arm). Try to inject on the same day each week, and choose a time of day you can consistently stick to. You can take Mounjaro 2.5mg with or without food

Want a full walk-through?

👉 See our step-by-step “how to take Mounjaro” page (and video)

✅ Keep in the fridge (2–8°C)
✅ Do not freeze
✅ If needed, you can store it at room temperature (up to 30°C) for up to 21 days
❌ Don’t use it past the expiry date
❌ Don’t leave it in direct sunlight or hot areas

• Week 1 – You may not feel much – or you may notice early appetite changes.
• Week 2–3 – Mild side effects (like nausea or bloating) may appear as your body adjusts.
• Week 4 – You’ll be reviewed for dose increase to 5mg – where greater weight loss often begins.

Most people tolerate 2.5mg well. But mild side effects can include:

• Nausea
• Feeling overly full
• Constipation or diarrhoea
• Fatigue
• Headache

These usually settle within 1-2 weeks. Stay hydrated, eat smaller meals, and avoid high-fat foods during this phase. If side effects are severe or don’t improve, contact your clinical team.

After 4 weeks on 2.5mg, your clinician will assess whether you’re ready to move up to 5mg – the first “therapeutic” dose for weight loss.

We’ll guide you through that decision when the time comes.

👉 Learn more about Mounjaro 5mg

While 2.5mg is most commonly used as a starting dose, there are situations where a clinician may recommend stepping back down to this lower dose temporarily.

Side effects at higher doses

If you’ve moved up to 5mg or beyond and are experiencing strong nausea, vomiting, fatigue, or other side effects that don’t settle, returning to 2.5mg for a short time may help your body reset. Once you feel better, you and your clinician can discuss trying a slower titration.

Tapering off Mounjaro

If you’ve reached your goal weight and are looking to reduce or stop treatment, 2.5mg may be used as a transition dose. This helps minimise appetite rebound while your body readjusts to producing hunger hormones naturally. This should always be done under clinical supervision.

Book a free call with our team to discuss any questions you may have about the Mounjaro 5mg dose.

Book a call today