Mysimba is manufactured by Orexigen Therapeutics, a pharmaceutical company with headquarters in California, USA.

The active ingredients of Mysimba are naltrexone hydroxide and bupropion hydrochloride. It is thought that bupropion reduces appetite, and naltrexone reduces food cravings. These effects also help patients stick with other weight loss treatments and behaviour change, such as dieting and exercise.

The active ingredients of Mysimba are naltrexone hydroxide and bupropion hydrochloride.

There are 8mg of naltrexone hydroxide and 90mg of bupropion hydrochloride in each Mysimba tablet.

The specific dosage and schedule will be determined based on individual needs and medical history. However, a typical treatment plan could start as follows:

Week 1: one tablet per day, taken in the morning

Week 2: two tablets per day, one in the morning, one in the evening

Week 3: three tablets per day, two in the morning, one in the evening

Week 4 and beyond (maintenance dose): four tablets per day, two in the morning, two in the evening

Please note that progression to stronger doses will be assessed individually and your clinician may increase your dose more slowly based on how well your body tolerates the medication.

In the UK Mysimba is not licensed for weight loss and weight management, but it is often prescribed by specialist clinics for this purpose if appropriate.

The active ingredients of Mysimba are naltrexone hydroxide and bupropion hydrochloride. It is thought that bupropion reduces appetite, and naltrexone reduces food cravings. These effects also help patients stick with other weight loss treatments and behaviour change, such as dieting and exercise.

For more information see the manufacturer’s Patient Information Leaflet for Mysimba.

Clinical trials have shown that Mysimba is effective in promoting weight loss. One trial showed that taking Mysimba for 16 weeks helped patients achieve 5% weight loss.

Anecdotally, many people who have taken Mysimba also report positive outcomes beyond clinical measures. As well as weight loss, patients frequently mention that their general quality of life has improved since taking Mysimba. For instance, some users have shared that they feel more energetic, have better mobility, and experience less joint pain. Others have highlighted the psychological benefits, such as increased confidence and reduced anxiety about their health.

Direct health benefits

• Significant weight loss can lower blood sugar levels and improve insulin sensitivity, reducing the risk of developing type 2 diabetes or aiding in its management.
• Weight loss often leads to reduced blood pressure, which decreases the risk of heart disease and stroke.
• Losing weight can improve cholesterol, reducing the risk of cardiovascular diseases.

Indirect health benefits

• Weight loss can relieve stress on joints and bones, making physical activities easier and reducing the risk of osteoarthritis.
• Many users report improved sleep quality and reduced sleep apnea symptoms.
• Weight loss can lead to better mental health outcomes, including reduced depression and anxiety.

Direct lifestyle benefits

• Losing weight makes it easier to engage in physical activities, which can further enhance weight loss and overall health.
• Users often report feeling more energetic and less fatigued.
• Many users enjoy the benefit of fitting into smaller-sized clothes and having a wider variety of clothing options.

Indirect lifestyle benefits

• Weight loss can increase confidence and encourage more social interaction, improving relationships and quality of life.
• People find they can travel more comfortably and participate in activities such as hiking, biking, or even simple walks that were challenging before.
• Increased energy and improved health can lead to better focus and productivity at work.

There are multiple reasons why Mysimba may not be suitable for some people, including:

• Pregnant or breastfeeding women 
• People with chronic malabsorption syndrome, as Mysimba prevents proper absorption of nutrients from food.
• People who have cholestasis
• Anyone allergic to Mysimba or any of Mysimba’s other ingredients should avoid it.
• Mysimba can interact with some medications, such as cyclosporine and warfarin, so those on these medications should consult their doctor before using it.
• those under 18 years of age or over 75 years old.

Mysimba is a prescription-only medication, and the decision to prescribe it rests with a healthcare provider. They will evaluate the patient’s overall health, medical history, and specific weight loss needs to determine eligibility. To see if you are eligible, start our online assessment.

Depending on your individual weight loss journey, your clinician might suggest that Mysimba weight loss treatment will be most effective when taken in combination with other weight loss methods. This may include adopting a healthy diet with fewer calories and increasing physical activity. Sustainable weight loss often requires a comprehensive approach that includes both medical treatment and lifestyle modifications.

In the UK Mysimba can be obtained from many local and online pharmacies as well as specialist weight loss clinics. Medicspot offers next day delivery of Mysimba across the UK subject to eligibility, and with the exception of a few of the more remote postcodes.

The cost of Mysimba from Medicspot is £89 for 112 tablets, which equates to between £2.54 and £3.18 per day depending on which dose you are taking. 

To put the price into context, the daily cost of orlistat is less than a cup of coffee.

Investing in Mysimba can lead to significant health benefits, potentially reducing medical expenses related to obesity-related conditions, such as diabetes, heart disease, and joint problems. Improved health can also enhance quality of life and productivity. You may also find you eat less as your appetite is suppressed, so your food spending might reduce.

Yes, Mysimba can be purchased online from licensed pharmacies. When buying online, ensure the pharmacy is reputable and registered with the General Pharmaceutical Council (GPhC) to avoid counterfeit medications. Please note that a clinical assessment and valid prescription is required in order to obtain Mysimba. To check if you are eligible, start your assessment now.

Mysimba is not available on the NHS as a weight loss treatment.

There is no legal or guideline maximum limit for how long you can take Mysimba.

Yes, Mysimba is legal in the UK.

Mysimba underwent clinical trials to evaluate its safety and efficacy. It was tested in multiple phases involving thousands of participants. These trials demonstrated that Mysimba is not only safe but also effective in aiding weight loss.

In the UK Mysimba is available by prescription but has not been licensed as a treatment for weight loss and weight management by the MHRA. Mysimba has received official approval from other regulatory bodies internationally such as the European Medicines Agency (EMA) in 2015.