Mounjaro vs Wegovy for Weight Loss

Mounjaro (tirzepatide) and Wegovy (semaglutide) are two medications that have been proven to be effective in aiding weight loss, in addition to managing type 2 diabetes. Both are injectables but they have some important differences. This detailed comparison will help you understand their differences, effectiveness, and other considerations when choosing between them.

When comparing the effectiveness of Mounjaro and Wegovy as weight loss treatments, clinical studies indicate that both can significantly reduce body weight.

• Mounjaro: Clinical trials have demonstrated that Mounjaro can lead to substantial weight loss, with some studies showing up to 26% of body weight reduction over 82 weeks when combined with a healthy diet and exercise.
• Wegovy: Clinical trials have shown that Wegovy can lead to weight loss of around 15-20% over a year, alongside lifestyle changes, making it one of the most effective weight loss medications available.

Both medications are highly effective, but Mounjaro offers a slight edge in percentage of body weight loss.

Mounjaro and Wegovy work through different mechanisms to aid in weight loss.

• Mounjaro: Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. It mimics both GIP and GLP-1 hormones, which help regulate appetite, slow gastric emptying, and increase insulin production, thereby reducing food intake and promoting weight loss. Its additional effect on GIP receptors results in altered fat metabolism, providing additional benefit in weight loss.
• Wegovy: Semaglutide is a GLP-1 receptor agonist alone. It mimics the GLP-1 hormone, which helps regulate appetite, slows gastric emptying, and increases insulin production in response to meals, thereby reducing food intake and promoting weight loss.

The cost of treatment with Mounjaro and Wegovy can vary based on factors such as location, insurance coverage, and the healthcare system.

• Mounjaro: Generally less expensive, ranging from £170-£190 per month.
• Wegovy: Typically costs more, around £170-£270 per month depending on the dosage strength.

Over a year, Mounjaro could cost around £2160, while Wegovy would be more like £2600.

Both Mounjaro and Wegovy have potential side effects, but they differ in nature due to their different mechanisms of action.

• Common side effects: Nausea, vomiting, diarrhoea, constipation, and stomach pain. Some patients may also experience headaches and dizziness. As these are injectable, there is the risk of needle-phobia, injection-site infections and localised reactions.
• Mounjaro: As a dual receptor agonist, it might have a broader range of gastrointestinal side effects initially, but these often subside as the body adjusts.
• Wegovy: Side effects are often related to its effect on the digestive system and appetite regulation.

Both medications have similar side effect profiles, with gastrointestinal issues being the most common.

• Mounjaro: Administered via injection once weekly, with the dosage gradually increased based on the patient’s response and tolerance.
• Wegovy: Also administered via injection once weekly, with doses increasing depending on a patient’s response.

Both medications provide a steady release of the active ingredient, making weekly injections convenient.

Both medications have similar guidelines regarding food and drug interactions.

• Mounjaro: Less impacted by food but can interact with other medications, particularly those affecting blood sugar levels. It’s important to follow dietary guidelines and consult with a healthcare provider to manage potential interactions.
• Wegovy: Similar to Mounjaro, with attention to managing other medications and potential interactions with foods.

Both Mounjaro and Wegovy are widely available in the UK with a prescription.

• Mounjaro: Available by prescription for weight loss and type 2 diabetes management.
• Wegovy: Available by prescription specifically for weight loss alone.

Mounjaro and Wegovy offer effective options for weight loss, each with unique features due to their different mechanisms. Mounjaro may offer slightly more significant weight loss due to its dual action but comes at a higher cost. Wegovy is also highly effective and generally less expensive.

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases the clinicians may contact you for additional information. See Terms of Service for more information.